Oxidized protein disulfide isomerase (PDI) facilitates disulfide bond formation in conjunction with endoplasmic reticulum oxidase 1 (Ero1), while GSH acts as a buffer to maintain the reduced form of PDI [50]
Y250 is located much farther from the disulfide bonds (Cys128-Cys206 in the hinge region between K1 and K2 domains, and Cys211-Cys288, Cys232-Cys271, and Cys260-Cys283 in the K2 domain) than the distances between Y198 and disulfide bonds, Cys149-Cys189 and Cys177-Cys201
10.1056/nejm199207023270104 N
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Tyson LD, Cheng A, Kelleher C, Strathie K, Lovendoski J, Habtemariam Z, et al